126 articles - From Friday Jun 17 2022 to Friday Jun 24 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
| Gastroenterology |
AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation. The panel agreed on 9 recommendations for the management of patients with IBS-C. The panel made a strong recommendation for linaclotide (high certainty) and conditional recommendations for tenapanor, plecanatide, tegaserod, and lubiprostone (moderate certainty), polyethylene glycol laxatives, tricyclic antidepressants, and antispasmodics (low certainty). The panel made a conditional recommendation against the use of selective serotonin reuptake inhibitors (low certainty). |
AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Diarrhea. The panel agreed on 8 recommendations for the management of patients with IBS-D. The panel made conditional recommendations for eluxadoline, rifaximin, alosetron, (moderate certainty), loperamide (very low certainty), tricyclic antidepressants, and anstispasmodics (low certainty). The panel made a conditional recommendation against the use of selective serotonin reuptake inhibitors (low certainty). |
| Gut |
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction. This international consensus on the new definitions of BO, GOJ and the GOJZ will be instrumental in future studies aiming to resolve many issues on this important anatomic area and hopefully will lead to better classification and management of the diseases surrounding the GOJ. |
| J Hepatol |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
Meta-analysis: global prevalence, trend and forecasting of non-alcoholic fatty liver disease in children and adolescents, 2000-2021. The prevalence of paediatric NAFLD varies by region and is 52.49% overall among the obese population and 7.40% in the general population. It is predicted to reach 30.7% by 2040. |
| Clin Gastroenterol Hepatol |
What Is the Prevalence of Clinically Significant Endoscopic Findings in Subjects with Dyspepsia? Updated Systematic Review and Meta-analysis. Erosive esophagitis was the most common clinically significant finding at EGD whereas gastro-esophageal cancers were rare. Most pathology, including esophagitis and cancer, were found in similar proportions in both groups. These findings support non-invasive approaches to managing dyspepsia in the community with EGD reserved for those at high risk of malignancy. |
| Gastroenterology |
Risk Factors for Abdominal Pain Disorders of Gut Brain Interaction in Adults and Children: A Systematic Review. There are multiple risk factors for AP-DGBI in adults and children. These include female sex, gastroenteritis, abuse, stress, poor sleep, obesity, psychological disorders and somatic symptoms. Additional studies are needed in children, on protective factors, and on factors associated with persistence of AP-DGBI. |
| J Neurogastroenterol Motil |
A Systematic Review of the Development and Psychometric Properties of Constipation-Related Patient-Reported Outcome Measures: Opportunities for Digital Health. The constipation-related PROMs identified in this review present varying quality of development and validation, with an overall need for improvement. Further considerations should be given towards more consistent methodology and reporting of PROM development, increase in culturally-specific PROMs, and better reporting of protocol for the digitisation of PROMs. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
A retrospective cohort study: pre-operative oral enteral nutritional optimisation for Crohn's disease in a UK tertiary IBD Centre. Oral EN was reasonably well tolerated and associated with a reduction in 30-day postoperative complications. Prospective randomised controlled trials are required to confirm these findings. |
Children included in randomised controlled trials of biologics in inflammatory bowel diseases do not represent the real-world patient-mix. Most children with IBD who initiate biologics would not have been eligible to be included in the corresponding regulatory RCTs. The outcomes of ineligible patients were worse than for eligible patients. Results from RCTs should be interpreted with caution when applied to clinical practice. |
HERACLIS-TAF: a multicentre prospective cohort study on 2-year safety and efficacy of tenofovir alafenamide in patients with chronic hepatitis B with renal and/or bone disorders or risks. In mostly switched patients with renal and/or BMD disorders/risks, eGFR improved after 12-24 months of TAF treatment, especially in patients with baseline eGFR 30-60 |
Improved survival of viral hepatocellular carcinoma but non-viral hepatocellular carcinoma from 2000 to 2020: A multicenter cohort study of 6007 patients from high-volume academic centers in Japan. The prevalence of non-viral HCC is increasing. Although the survival of patients with viral HCC improved significantly over the past two decades, there was no improvement in patients with non-viral HCC. This was presumably due mainly to lower surveillance among patients with non-viral HCC and failure to diagnose early-stage HCC. |
Salivary microbiota composition may discriminate between patients with eosinophilic oesophagitis (EoE) and non-EoE subjects. Our preliminary data suggest that salivary metabarcoding analysis in combination with machine learning approaches could become a valid, cheap, non-invasive test to segregate between EoE and non-EoE patients. |
Switching to tenofovir alafenamide for nucleos(t)ide analogue-experienced patients with chronic hepatitis B: Week 144 results from a real-world, multicentre cohort study. Switching to TAF remained effective and safe for up to 3 |
Synchronous occurrence of different polyp types during colonoscopy. Different types of colon polyps commonly coincide in individual patients. The present set of data from a large nationwide database may provide guidance for the endoscopist of what variety in colon polyps to expect during colonoscopy. |
| Clin Gastroenterol Hepatol |
Incidence of Type 2 Diabetes in Children with Nonalcoholic Fatty Liver Disease. Children with NAFLD are at high risk for existing and incident T2D. In addition to known risk factors for T2D (females and BMI z-score), severity of liver histology at the time of NAFLD diagnosis was independently associated with T2D development. Targeted strategies to prevent T2D in children with NAFLD are needed. |
Racial and Ethnic Disparities in Early-Onset Colorectal Cancer Survival. Our study adds to the well-documented disparities in CRC in older adults by demonstrating persistent racial/ethnic disparities in relative survival and all-cause mortality in patients with early-onset CRC. |
| Endoscopy |
Risk scoring system for the pre-procedural prediction of clinical failure of peroral endoscopic myotomy: a multicenter case-control study. This risk scoring system can predict clinical failure of POEM preoperatively and provide useful information for making treatment decisions. |
| Gastroenterology |
Altered mycobiota signatures and enriched pathogenic Aspergillus rambellii are associated with colorectal cancer based on multi-cohort fecal metagenomic analyses. This study reveals enteric mycobiota signatures and pathogenic fungi in stages of colorectal tumorigenesis. Fecal fungi can be utilized, in addition to bacteria, for non-invasive diagnosis of CRC patients. |
Dual stromal targeting sensitizes pancreatic adenocarcinoma for anti-PD-1 therapy. This represents the first preclinical study to identify synergistic effects of targeting both intracellular and extracellular components within the PDAC stroma and supports testing anti-CXCR4 antibody in combination with FAKi as a PDAC treatment strategy. |
Exhaustion of CD39-expressing CD8+ T cells in Crohn's disease is linked to clinical outcome. These data show a role for the exhaustion of peripheral CD39-expressing CD8 T cell subsets in CD. Their low frequency illustrates the utility of single-cell cytometry methods for identification of relevant immune populations. Importantly, the link of their exhaustion status to the clinical activity and their specific gene signatures have implications for exhaustion-based personalized medicine approaches. |
| Gastrointest Endosc |
Bacterial contamination and organic residue after reprocessing in duodenoscopes with disposable distal caps compared to duodenoscopes with fixed distal caps: a randomized trial. After manual cleaning, duodenoscopes with disposable distal cap had significantly lower BC and organic residue than duodenoscopes with fixed distal cap. Only a few duodenoscopes from each group did not pass the ATP threshold after HLD. |
Biopsy channel of the endoscope as a potential source of infectious droplets during gastrointestinal endoscopy. We found that the biopsy channel may be a source of infectious droplets, especially during the removal of instruments from the biopsy channel. When compared with droplets reported from the mouth and anus, these droplets were larger in size and therefore potentially more infectious. |
Comparison of focal cryoballoon ablation with 10 and 8 second dose for treatment of Barrett's esophagus related neoplasia: results from a prospective European multicenter study. In patients with limited BE, single-session FCBA with 8s showed similar BE surface regression as compared to 10s, and may theoretically result in fewer and less severe strictures. Therefore, we suggest to use 8s as the standard dose for FCBA. |
Development of a Deep Learning Model for the Histological Diagnosis of Dysplasia in Barrett's Esophagus. We successfully trained and validated a deep learning model to accurately identify dysplasia on whole slide images. This model can potentially help improve the histologic diagnosis of BE dysplasia and the appropriate application of endoscopic therapy. |
Endoscopic mucosal resection combined with hybrid argon plasma coagulation to prevent recurrence of large nonpedunculated colorectal polyps. EMR with h-APC showed a high technical success rate, low complication rate, and very low post-EMR recurrence rates. Study registration Trial registered at Montreal University Research Center Institutional Review Board (19.119) and at ClinicalTrials.gov (NCT04015765). |
Endoscopic Resection of Upper Gastrointestinal Extraluminal Tumors. Endoscopic resection is a safe and feasible therapeutic approach for upper gastrointestinal extraluminal tumors. Tumor size, shape, and location impact the difficulty and safety of the procedure. Endoscopic resection of duodenal tumors is also feasible but associated with an increased risk of AEs, compared with tumors in other locations. |
Environmental and Health Outcomes of Single-Use versus Reusable Duodenoscopes. Although SDs may provide incremental public health benefit compared to RD, it comes at a substantially higher cost to the environment. As infection rate continues to decrease from more regimented cleaning protocols and enhanced designs such as disposable endcaps to facilitate cleaning, the negative impact to human health from contaminated RDs could be comparable to SDs. |
Implementation of optical diagnosis with a 'resect and discard strategy' in clinical practice: DISCARD3 study. A "resect and discard" strategy for high confidence =5mm polyp OD, in a group of bowel cancer screening colonoscopists, is feasible and safe with performance exceeding the 90% surveillance interval concordance required for implementation in clinical practice. |
| Gut |
Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases. Neutralising the effects of IL-10 in human CRLM has therapeutic potential as a stand-alone treatment and to augment the function of adoptively transferred CAR-T cells. |
Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models. The CCi/CMi phenotype has a critical role in malignant transformation and tumour progression, offering new mechanistic information on RHO-ROCK pathway inhibition that contributes to GC pathogenicity. |
Protective and aggressive bacterial subsets and metabolites modify hepatobiliary inflammation and fibrosis in a murine model of PSC. Goal define the function of complex resident microbes and their association relevant to PSC patients by studying germ-free (GF) and antibiotic-treated specific pathogen-free (SPF) multidrug-resistant 2 deficient ( mice and PSC patients with associated clinical risk score. These insights may guide personalised targeted therapeutic interventions in PSC patients. |
| Hepatology |
Apolipoprotein F Is Reduced in Humans with Steatosis and Controls Plasma Triglyceride-Rich Lipoprotein Metabolism. These data reveal a previously undescribed role for ApoF in the control of plasma and hepatic lipoprotein metabolism by favoring VLDL-TG secretion and hepatic lipoprotein remnant particle clearance. |
Circulating TREM2 as a non-invasive diagnostic biomarker for NASH in patients with elevated liver stiffness. Plasma TREM2 is a plausible individual biomarker that can rule-in or rule-out the presence of NASH with high accuracy and thus has the potential to reduce the need for liver biopsies and to identify patients who are eligible for clinical trials in NASH. |
Eosinophils protect against acetaminophen-induced liver injury through cyclooxygenase-mediated IL-4/IL-13 production. The current study revealed that eosinophil-derived IL-4/IL-13 accounted for the hepato-protective effect of eosinophils during AILI. The data demonstrated that the p38MAPK/COX/NF- |
Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cells. Our results imply that the disassembly of cytoplasmic HBV nucleocapsids is restricted in murine hepatic cells. Overcoming this limitation may help to establish an HBV infection mouse model. |
Proteogenomic Characterization of Cholangiocarcinoma. We characterized the proteogenomic landscape of 217 CCAs with 197 paired normal adjacent tissues and identified their subtypes and potential therapeutic targets. The multi-omics analyses with other databases and some functional validations have indicated strategies regarding the clinical, biological, and therapeutic approaches to the management of CCA. |
Retracted: Posttranslational regulation of polycystin-2 protein expression as a novel mechanism of cholangiocyte reaction and repair from biliary damage. The retraction has been agreed upon due to recently verified concerns regarding data authenticity rendering the conclusions uncertain. Several figures included in the article were found to have been falsified. |
SDHA/B reduction promotes hepatocellular carcinoma by facilitating the deNEDDylation of cullin1 and stabilizing YAP/TAZ. Our study demonstrated that SDHA/B reduction promotes HCC proliferation by preventing the proteasomal degradation of YAP/TAZ through modulating cullin1 NEDDylation, thus addicts SDH-deficient HCC cells to YAP/TAZ pathway and renders these cells vulnerable to YAP/TAZ inhibition. Our findings warrant further investigation on the therapeutic effects of targeting YAP/TAZ in HCC patients displaying reduced SDHA/B or elevated succinate levels. |
| Inflamm Bowel Dis |
A Serum Biomarker Panel Can Accurately Identify Mucosal Ulcers in Patients With Crohn's Disease. The EHI was independently associated with ulcer size and accurately identified large or very large ulcers. A cutoff of 50 points can reliably rule in mucosal ulcers and allow for treatment adjustment. A cutoff of 20 points can reliably rule out mucosal ulcers and signal completion of treatment adjustment algorithms. |
Managing Inflammatory Bowel Disease in Pregnancy: Health Care Professionals' Involvement, Knowledge, and Decision Making. Despite "good" theoretical pregnancy-related IBD knowledge as assessed by CCPKnow, applied knowledge in the scenarios was less consistent. There is need for further HCP education and clinical experience to achieve optimal standardized care for IBD in pregnancy. |
Medical and Surgical Implications of Mesenteric Adipose Tissue in Crohn's Disease: A Review of the Literature. Nonetheless, the results are promising and potentially have important implications for the medical and surgical management of CD, which merits that additional studies are warranted. Thus, we have reviewed the available literature on the medical and surgical implications of MAT in CD to summarize our current understanding and identify gaps in knowledge to inform future investigations. |
| J Crohns Colitis |
Aberrant mesenteric adipose extracellular matrix remodeling is involved in adipocyte dysfunction in Crohn's disease: The role of TLR-4-mediated macrophages. The aberrant ECM remodeling in CD-htMAT contributed to mesenteric adipocyte dysfunction, which may be caused at least partly by TLR4-mediated macrophage remodeling behavior. Inhibiting ECM remodeling may be a potential therapeutic strategy for CD. |
Intraabdominal septic complications after ileocolic resection increases risk for endoscopic and surgical postoperative Crohn's disease recurrence. IASC is associated with an increased risk for endoscopic and surgical POR of Crohn's disease. Preoperative optimization to prevent IASC, in addition to postoperative biologic prophylaxis, may help reduce risk for endoscopic and surgical POR. |
Novel Budesonide Suppository and Standard Budesonide Rectal Foam Induce High Rates of Clinical Remission and Mucosal Healing in Active Ulcerative Proctitis, a Randomised, Controlled, Non-inferiority Trial. In patients with ulcerative proctitis, budesonide 4 mg suppository was non-inferior to budesonide 2 mg foam in efficacy, and both were safe and well tolerated. EudraCT no. 2016-001921-15. |
Safety of ustekinumab and vedolizumab during pregnancy - pregnancy, neonatal and infant outcome: a prospective multicenter study. Use of ustekinumab and vedolizumab in pregnancy seems to be safe, with favorable pregnancy and postnatal infant outcomes. Placental transfer differed between these two drugs, with ustekinumab having similar and vedolizumab having inverse infant-to-maternal ratio of drug levels compared to anti-TNF preparations. |
| J Hepatol |
Hepatitis B virus-specific CD4 T-cell responses differentiate functional cure from chronic surface antigen+ infection. Functional cure in chronic HBV infection is associated with higher frequencies of functional HBV-specific CD4 memory T-cell responses compared to chronic HBV infection. The data support that immunotherapeutic approaches to induce HBV functional cure should also aim to improve CD4 T-cell responses. |
Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy. GSK3389404 showed an acceptable safety profile and target engagement, with dose-dependent reductions in HBsAg. However, no efficacious dosing regimen was identified. Clinical trial number NCT03020745 |
SLC25A47 is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. Collectively, our data place SLC25A47 at the center of mitochondrial homeostasis, which upon dysfunction triggers robust liver-specific and systemic adaptive stress responses. The prominent role of SLC25A47 in hepatic fibrosis identifies this carrier, or its transported metabolite, as a potential target for therapeutic intervention. |
| Neurogastroenterol Motil |
High-resolution in vivo monophasic gastric slow waves to quantify activation and recovery profiles. A novel high-resolution multi-channel suction electrode array was developed and applied in vivo to record monophasic gastric slow waves. Slow wave recovery phase analysis could be performed more efficiently on monophasic signals compared with biphasic signals, due to the more identifiable recovery phases. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
| Clin Gastroenterol Hepatol |
| Gastroenterology |
Recent Advances in the Study of Extracellular Vesicles in Colorectal Cancer. We will then summarize the cargo found in small (s)EVs released from CRC cells and other cells in the tumor microenvironment (TME), as well as those found in the circulation of CRC patients. Finally, we will consider the continuing challenges and future opportunities in this rapidly evolving field. |
| Gastrointest Endosc |
| Gut |
| Hepatology |
Implementation of a Controlled Human Infection Model for Evaluation of HCV Vaccine Candidates. Importantly, the study design (including number of volunteers required, cost, duration of study and risk to volunteers) varies significantly depending on the proposed mechanism of action (sterilizing/rapid viral clearance vs delayed viral clearance) of the vaccine under evaluation. We conclude that an HCV CHIM is now realistic, that safety and ethical concerns can be addressed with the right study design, and that without an HCV CHIM it is difficult to envisage how the development of an HCV vaccine will be possible. |
Noncellular components in the liver cancer stem cell niche: biology and potential clinical implications. In this review, we highlight how various noncellular components in the TME play a role in regulating CSCs and how CSCs secrete components to interact with the TME to generate their own niche, working hand-in-hand to drive tumor physiology in HCC. In addition, we describe the potential clinical applications of these findings and propose perspectives on future research of noncellular components in the liver CSC niche. |
Patient-Centered Care: Key Elements Applicable to Chronic Liver Disease. Payers need to partner with providers and systems to build upon these elements and help align reimbursements with patient's values and outcomes. The national organizations such as the American Association for Study of Liver Diseases need to guide key stakeholders in standardizing these elements to optimize patient-centered care for CLD. |
| J Hepatol |
| J Neurogastroenterol Motil |
Enterochromaffin Cells-Gut Microbiota Crosstalk: Underpinning the Symptoms, Pathogenesis, and Pharmacotherapy in Disorders of Gut-Brain Interaction. We explored the knowledge gap and attempted to suggest new perspectives of physiological and pathophysiological insights of DGBIs, such as (1) functional heterogeneity of regionally distributed EC cells throughout the entire GI tract; (2) potential pathophysiological mechanisms mediated by EC cell defect in DGBIs; (3) cellular and molecular mechanisms characterizing EC cells and gut microbiota bidirectional communication; (4) differential modulation of EC cells through GI segment-specific gut microbiota; (5) uncover whether crosstalk between EC cells and (i) luminal contents; (ii) enteric nervous system; and (iii) central nervous system are core mechanisms modulating gut-brain homeostasis; and (6) explore the therapeutic modalities for physiological and pathophysiological mechanisms mediated through EC cells. Insights discussed in this review will fuel the conception and realization of pathophysiological mechanisms and therapeutic clues to improve the management and clinical care of DGBIs. |
Letters to the editors and authors’ replies
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
all remaining publications eg case reports, images of the month, etc…
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| Inflamm Bowel Dis |
| J Crohns Colitis |
| J Hepatol |